Our review article written by Dr Pamela Bowman, Dr Jonna Mannisto and Dr Sarah Flanagan is out which describes how studying neurodevelopmental outcomes in people with congenital hyperinsulinism could inform more generally on the effects of hypoglycaemia on neurodevelopment in...

Congratulations to Michaelis Vasiliadis for winning the Poster Prize (a brand-new lab coat!) at the 9th Annual Mutational Scanning Symposium in Melbourne! 🎉 Michaelis presented some of his work aimed at improving our understanding of the disease mechanism behind the...

The Exeter Centre for Hyperinsulinism Genetics are offering an undergraduate student the opportunity to join our team for a paid 8 week summer placement through the Genetics Society/BBRSC Research Access Placement Scheme. Undergraduates who meet the following criteria are able...

Our new preprint describing a 94 bp deletion in the SLC16A1 gene as a recurrent cause of adult-onset hyperinsulinism has been published. This research study started with a family-led question and has led to changes in the way we think...

Congratulations to Isabella Lazaridi a PTY student in the Exeter Centre for Hyperinsulinism Genetics who won not just one award but three! The Society for Endocrinology PTY Project Prize- BSc Medical Sciences, the Medical Science Year Prize and a Deans...

Some of the HI genes team were lucky enough to travel to Liverpool and take part in the CHI family conference.

Team away day. What a great day, we even managed to dodge the summer showers!

Jasmin, Jayne, Evgenia and Sarah from the Exeter team were honoured to have been invited to attend the 2023 Children’s Hyperinsulinism Charity family event.  A fantastic opportunity to share our work and also to learn from the families who are…

Tom visits Queen Elizabeth’s School to speak to local students about the HI research and to provide some useful insights into studying Medicine and Medical Sciences.

The Open Hyperinsulinism Genes Project Nominated by Dr Sarah Flanagan. Partnered with Congenital Hyperinsulinism International and The Genomics Laboratory Congenital Hyperinsulinism is a life-threatening condition where too much insulin causes dangerously low blood sugar. Genetic testing is required to guide medical management….

Tom Laver organised and chaired an invited session on penetrance of monogenic disease at the ASHG international genetics conference to a live audience of over 500 people.

Sarah, Tom and Jayne attend the first virtual Congenital Hyperinsulinism Family Conference. A great opportunity to talk to healthcare professionals and families about the important role of genetics in this condition.

The HIgenes team are continuing with their outreach efforts. Tom talks to students at Queen Elizabeth’s School about  “When genes go wrong: genetic testing in diabetes and hyperinsulinism”. During his talk he highlighted many of the benefits of pursuing a...

Sarah attends the Congenital Hyperinsulinism International Family Conference in Vienna. A wonderful opportunity to learn from families affected by this condition and to learn about the impact of our research.

Tom is at the European Society of Human Genetics meeting in Sweden showcasing his work on CNVs in hyperinsulinism.

We are in Prague attending the 7th Meeting of the EASD Study Group on the Genetics of Diabetes. Great talks from the HIgenes team including an overview of hyperinsulinism in Kabuki syndrome from Jayne Houghton followed by a presentation from...

Sarah shares the latest exciting research findings from the HIgenes team with other Sir Henry Dale Fellows at the Wellcome Trust.

The HIgenes team attended the Paediatric Endocrinology Symposium on Hypoglycaemia. It was great to give a lecture detailing the role of genetics in Hyperinsulinism.

It is outreach month for the HI genes team. Sarah and Tom have been busy passing on their enthusiasm for science to students at Exeter School and Queen Elizabeth’s School in Crediton, UK.

Tom presents his work on Chromosome 20 deletions in hyperinsulinism at the American Society of Human Genetics conference in San Diego, USA. Congratulations Tom on receiving a ‘Reviewer’s Choice’ Award.

It’s that time of year again to raise some money for an extremely worthwhile cause #JeansforGenes.

The HI genes team are extremely pleased to announce that they have teamed up with the Charitable Organisation, Congenital Hyperinsulinism International. The Exeter team have received generous funds donated by CHI which will allow them to provide genetic testing to...

Sian attends the Congenital Hyperinsulinism International Family Conference in Athens. A great opportunity to highlight the importance of genetics in the condition and to learn from families.

Sarah attended the Children’s Hyerinsulinism Charity, Bringing Families Together Conference. It was a great opportunity for talk to the families about the underlying genetic causes of the disorder and to learn from their experiences

HUGE CONGRATULATIONS to Sian who has been awarded an OBE in the Queen’s birthday honours list. The team had great fun helping Sian celebrate in sunny Exeter.

Jayne Houghton provides a great training session to the diagnostic team at the RD&E Hospital on occurrence of hyperinsulinism in Kabuki syndrome.

Tom Laver helps to bring science to the masses at the University of Exeter ‘Pint of Science’ event. Standing room only for his talk on ‘When genes go wrong, learning from rare disease’.

Sarah Flanagan has been selected to receive the G.B. Morgagni Young Investigator Award, a prize which celebrates exceptional research in the field of metabolic diseases. The prize is named after Giovanni Battista Morgagni who was one of the first scientists...

Woolly hats off to our great team who braved the snow to keep the Exeter laboratory open. Here is their innovative attempt to create more staff!

The Exeter Monogenic Diabetes Training course was a great success. Over 100 delegates from 12 different countries attended the two day symposium where they learnt how to better diagnose and manage this condition. The role of HNF4A in congenital hyperinsulinism...

Our new paper describing a pathogenic variant in the MAFA gene in families with insulinomatosis and diabetes is receiving some good media attention. This important finding provides insights into the role of MAFA in the pancreatic beta cell. The early...

The HI Genes team kick off the new year by attending the University of Exeter’s Institute of Biomedical Sciences retreat held at the beautiful Dartington Hall. Sarah gave an overview of the team’s work and Tom presented a poster on...

We are supporting World Diabetes Day. Diabetes affects the lives of many individuals diagnosed with congenital hyperinsulinism. Up to 53% of individuals develop hyperglycaemia following near-total pancreatectomy and for some, this will progress to insulin-treated diabetes. Individuals with dominantly inherited...

The HIgenes team and it’s honorary members put on their running shoes to raise money for the Children’s Hyperinsulinism charity. We had over 25 runners from Exeter who ran either 5K, 10K or 21K. Thanks to everyone involved.

Sarah attends the Endocrine First Global summit in Athens, Greece. This was a great opportunity to meet with collaborators and many of the lovely clinicians who refer patients to Exeter for genetic testing.

There is still plenty of time to sign up for Halloween HI-ke. A virtual 5K, 10K or half-marathon race. All proceeds go to the Hyperinsulinism Charity. It’s a fantastic cause so please help to support this if you can (See...

Tom represents the HIgenes team at the EASD-Study Group on Genetics of Diabetes conference in Leiden. During the meeting, Tom presented his work on investigating the role of variants in UCP2 in individuals with congenital hyperinsulinism.

Ten months since its launch and we have received our 1000th visitor to the HIgenes website. We are always trying to improve the content of website so if you have any suggestions or comments please email them directly to S.Flanagan@exeter.ac.uk.

Congenital Hyperinsulinism International release a behind the scenes video showing the process of genetic testing for Hyperinsulinism in the Exeter Laboratory.

Anna Bussell, an MSc Student at the University of Exeter, has joined the HIgenes research group. Welcome to the team Anna!

To mark World Diabetes Day Sian describes the teams work researching the genetic causes of neonatal diabetes and hyperinsulinism for the University of Exeter Medical School Facebook page. To see the video click here.

The HIgenes team had the pleasure of welcoming Julie Raskin, Davelyn Hood and Janna Pelle from Congenital Hyperinsulinism International to Exeter. After a tour of the laboratory and discussions around the research taking place in Exeter the team learnt about...

Sian attends the Congenital Hyperinsulinism International Family Conference in Paris where she explains about the crucial role of genetics in this condition.

Sarah talks to the Exeter Molecular Genetics Diagnostic team (those that do all of the hard work!) about the importance of genetic testing in individuals with congenital hyperinsulinism.

Sarah talks to the Genetic Diabetes Nurses at the Exeter study day on the role of HNF1A mutations in congenital hyperinsulinism.

Sian and Sarah attend the 2016 ‘Congenital Hypoglycaemia Disorders: Hyperinsulinism and GSD’ professional conference hosted by the Children’s Hospital of Philadelphia and the Congenital Hyperinsulinism International (CHI) family day conference.

Sarah explains her work on congenital hyperinsulinism to colleagues at the Living Systems Institute Research Symposium at the University of Exeter.